C# Breakpoints not getting hit on initial page load ONLY

Subject says it all.  Two questions:

1. Breakpoints work fine once I go to browser and reload the page.  What could cause this?
2. I could not find a single instance of this issue being raised anywhere on the net.  I seem to have this type of thing happen often.  Do I win some kind of prize?

A little more info:

a) Using Visual Studio 2019 Community.

b) Have Resharper Ultimate installed.

Thanks for any help!  :)

Bill Nolan

Phoenix, AZ